Assess the single dose PK and safety of TR701 FA in subjects with Moderate or Severe hepatic impairment versus matched control subjects with normal hepatic function.

This study will assess the single-dose pharmacokinetics (PK) and safety of TR-701 free acid (FA) in subjects with Moderate or Severe hepatic impairment compared with matched control subjects with normal hepatic function.

Inclusion Criteria:

• Moderate or severe hepatic impairment or matched control
• BMI between 18.0 and 40.0 kg/m2

Exclusion Criteria:

• Evidence of acute deterioration of hepatic function within 8 weeks
• ALT or AST ≥ 5 times upper limit of normal for moderates; ALT or AST ≥ 8 times upper limit of normal for severes
• Total bilirubin > 5 mg/dl for moderates; no upper limit for severes
• Hemoglobin < 10g/dl for moderates; Hemoglobin < 9g/dl for severes