The purpose of this study is to assess the efficacy of a Deep Shaped-Field repetitive transcranial magnetic stimulation (DSF-rTMS) system in the treatment of depression.

Inclusion Criteria:

• Major depressive disorder (MDD)
• Mild to moderate level of resistance or intolerance to antidepressant treatment in the current episode.
• Will not become pregnant during study.

Exclusion Criteria:

• Seizure disorder.
• History of brain injury or active CNS disease.
• Metal implants on or in brain, spinal cord, ear, eye or heart.
• Current use of proconvulsant medications (e.g., bupropion).
• Other significant psychiatric disorder.
• Substance use disorder (not including caffeine or nicotine).
• 7 or more failed treatment attempts for depression in one's lifetime.
• Have failed to clinically remit to an adequate trial of ECT or TMS.