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Cardiac resynchronisation therapy (CRT) is an established treatment for improving symptoms in patients with congestive heart failure (CHF) by left ventricular (LV) pacing. CRT can help to improve LV function in patients with heart failure if those regions of the myocardium which are most compromised by electromechanical dyssynchrony can be identified and effectively stimulated. There still remains, however, a significant rate of up to 30% of patients who do not respond to treatment. Reasons for lack of benefit can be related to the inability of identifying and effectively stimulating those regions of myocardium, which are most compromised by electromechanical dyssynchrony. The investigators hypothesize that by using cardiac MR and 3D echo to identify scar, reconstruct coronary sinus anatomy, and determine the site of latest LV activation, the investigators can find the best place to implant the left ventricular lead. By avoiding scar and pacing in the site of latest activation, the investigators believe the investigators will reduce dyssynchrony and thus improve overall heart function. The researchers thus aim to increase the proportion of people who respond to treatment. The researchers also believe that the procedure may be streamlined so as to reduce procedure duration, radiation dose and dose of iodinated contrast medium.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard LV lead placement | Active Comparator |
| |
| Advanced Imaging Guided LV Lead Placement | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Advanced Imaging Guided LV lead placement | Other | Use of MRI to identify scar and latest activating LV segment as well as CS anatomy. This will be used to guide LV lead placement real-time. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in the proportion of CRT responders | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in echo derived end systolic (ESV) and diastolic volumes | 6 months | |
| Six month assessment of change in 6 minute walk distance and VO2 max (CPEX) | 6 months | |
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Manav Sohal, MBBS | Contact | +442071887188 | manav.sohal@gstt.nhs.uk |
| Name | Affiliation | Role |
|---|---|---|
| Christopher Aldo Rinaldi, MD | Guy's and St Thomas' NHS Foundation Trust | Principal Investigator |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Standard LV lead placement | Device | Standard LV lead placement not guided by advanced imaging |
|
| Procedural success |
| 0 months |
| Procedure duration | 0 months |
| Radiation dose | 0 months |
| Contrast dose | 0 months |
| Procedural complications | 6 months |