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The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
We have previously shown, using transcranial doppler, that coronary angiography cause cerebral microembolism. Cerebral microemboli were more common using the radial than femoral approach. Previously, cerebral microembolism has been associated with new cerebral lesions on MRI. The clinical significance of these new lesions is not determined. The primary aim of this pilot study is to see if coronary angiography cause cognitive dysfunction determined by the MoCA-test. A secondary aim is to relate cognitive dysfunction to cerebral microembolism measured by transcranial doppler. A third aim is to study potential differences between the femoral and radial approaches.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coronary angiography | Patents scheduled for elective coronary angiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arterial approach | Procedure | Randomization to right radial or femoral approach |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in cognitive dysfunction from baseline to two days after coronary angiography | The Montreal Cognitive Assesment test will be performed before, 2 and 30 days after coronary angiography | Baseline and two days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with cerebral microemboli | Cerebral microembolism will be studied by transcraniell doppler at the time of angiography. Findings will be related to change in cognitive function between baseline and two days. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for elective coronary angiography at one center
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| Name | Affiliation | Role |
|---|---|---|
| Per - Tornvall, MD, PhD | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiology Clinic, Karolinska University Hospital | Stockholm | 17176 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21393589 | Background | Jurga J, Nyman J, Tornvall P, Mannila MN, Svenarud P, van der Linden J, Sarkar N. Cerebral microembolism during coronary angiography: a randomized comparison between femoral and radial arterial access. Stroke. 2011 May;42(5):1475-7. doi: 10.1161/STROKEAHA.110.608638. Epub 2011 Mar 10. |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D006349 | Heart Valve Diseases |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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