Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)
Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)
RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.
OBJECTIVES:
OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.
DISEASE CHARACTERISTICS:
Tumor tissue samples from children with rhabdomyosarcoma (RMS) enrolled in the Children's Oncology Group clinical trials
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY: