Pharmacokinetics Study of Dapsone-Adapalene Fixed Combination Gel in Acne

This study will investigate the pharmacokinetics, safety and tolerability of dapsone and adapalene following topical administration of 2 formulations of dapsone/adapalene fixed combination gel, dapsone 5% gel (ACZONE®), and adapalene 0.3% gel (Differin®) in subjects with acne vulgaris.

Inclusion Criteria:

• Moderate acne on the face
• Willing to avoid swimming during the study
• Willing to avoid excessive sunlight and ultraviolet light (e.g., tanning beds)during the study
• Willing to avoid moisturizers, sunscreens, cosmetics, and chemical peels during the study

Exclusion Criteria:

• Severe cystic acne
• Use of topical or oral retinoids within 4 weeks
• Use of isotretinoin within 3 months
• Use of dapsone or adapalene within 3 months
• Anticipated need to engage in activities/exercise that would cause profuse sweating
• Donated blood or equivalent blood loss within 90 days