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Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mw. | Experimental | Administration of immunomodulator Mw. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mycobacterium w.(Mw)-freeze dried extract 0.5ml | Drug | 0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in all aspects of visual function | upto 6 months |
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Inclusion Criteria:
Unilateral Steroid Resistant Optic Neuritis
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bakulesh M Khamar, M.S. Ophthalmology | Thakore Eye Hospital, Ahmedabad | Principal Investigator |
| Mayuri B Khamar, M.S.Ophthalmology | M & J Institute Of Ophthalmology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sudhalkar Eye Hospital | Vadodara | Gujarat | 390001 | India |
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| ID | Term |
|---|---|
| D009902 | Optic Neuritis |
| D011681 | Pupil Disorders |
| ID | Term |
|---|---|
| D009901 | Optic Nerve Diseases |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| C000625648 | Immuvac |
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|
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |