Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to provide both offline and online soft-tissue-based image guidance. Such images will provide a significantly more complete picture of the spatial and temporal changes in thoracic anatomy. This more complete information will lay the groundwork for better radiotherapy planning and dose delivery in the presence of respiratory motion.

Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be acquired. MR acquisition will be performed without extrinsically administered contrast, using a balanced turbo field echo (TFE) sequence and commercially available coils.

Inclusion Criteria:

• AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using radiotherapy will be eligible for this study.
• Any types and amounts of prior therapy will be allowed for this study.
• Subjects must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
• Ability to understand and the willingness to sign a written informed consent document.
• Able to tolerate supine position
• ECOG performance status of 3 or less

Exclusion Criteria:

• MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
• Women who are pregnant or trying to get pregnant
• Pain in supine position