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| Name | Class |
|---|---|
| Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam | OTHER |
| Children's Hospital Number 1, Ho Chi Minh City, Vietnam | OTHER |
| Number 2 Children's Hospital, Ho Chi Minh City | OTHER |
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A study of dengue in children presenting to outpatient departments of 5 large hospitals in Ho Chi Minh City and Tien Giang province, Viet Nam.
Different blood tests are compared at the early stages of dengue fever onset in their ability to accurately and specifically detect children whose dengue will progress to severe disease.
In a prospective study in the outpatients department of three large hospitals in Ho Chi Minh City, Viet Nam, we will determine the early diagnostic sensitivity, specificity, positive and negative predictive values of two NS1 diagnostic tests in severe dengue cases.
The study is intended to develop a prognostic algorithm for the early identification of severe dengue cases.
Routine demographic, haematological and biochemical laboratory markers will be utilized to derive a prognostic algorithm that is clinically-useful for guiding patient triage and interventions.
We hope to discover and evaluate new early biomarkers of severe dengue and will evaluate candidate host response molecules and virological markers for their prognostic value.
We further plan to understand the phylogeography of DENV in the super-urban setting of HCMC.
We will use genome scale sequencing of DENV together with geospatial information on the residential addresses of patients to better understand transmission dynamics in space and time in a high transmission super-urban district of HCMC and thereby identify opportunities for public health interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Suspected dengue fever | Children aged 1-15 presenting at participating hospitals with symptoms of dengue fever |
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| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity of the NS1 detection assays for diagnosis of laboratory-confirmed severe dengue. | Percentage of detection assays which correctly predict laboratory-confirmed severe dengue. | Within the first 72 hours of fever onset |
| Specificity of the NS1 detection assays for diagnosis of laboratory-confirmed severe dengue. | Percentage of detection assays which correctly predict different dengue serotypes. | Within the first 72 hours of fever onset |
| Positive predictive values of the NS1 detection assays for diagnosis of laboratory-confirmed severe dengue. | Percentage of detection assays which correctly predict dengue infection. | Within the first 72 hours of fever onset |
| Negative predictive values of the NS1 detection assays for diagnosis of laboratory-confirmed severe dengue. | Percentage of detection assays which correctly predict no dengue infection. | Within the first 72 hours of fever onset |
| Measure | Description | Time Frame |
|---|---|---|
| Positive predictive values of the NS1 detection assays for children requiring hospitalization or parenteral fluid therapy. | Percentage of detection assays which correctly predict requirement of hospitalization and/or parenteral fluid therapy (dehydration, vomiting or signs of capillary permeability). | Estimated within 6 days of presentation |
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Inclusion Criteria:
Exclusion Criteria:
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Patient presenting to outpatient department of participating hospitals with symptoms of dengue fever
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| Name | Affiliation | Role |
|---|---|---|
| Cameron Simmons, PhD | Oxford University Clinical Research Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital for Tropical Diseases | Ho Chi Minh City | Ho Chi Minh | Vietnam |
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| Label | URL |
|---|---|
| Oxford University Clinical Research Unit | View source |
| Study details and Informed Consent Form | View source |
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| ID | Term |
|---|---|
| D003715 | Dengue |
| D004194 | Disease |
| ID | Term |
|---|---|
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D007239 | Infections |
| D001102 | Arbovirus Infections |
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| Tien Giang Provincial Hospital, Tien Giang, Viet Nam | UNKNOWN |
| Red Cross Clinic Of District 8 | OTHER |
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| Negative predictive values of the NS1 detection assays for children requiring hospitalization or parenteral fluid therapy. |
Percentage of detection assays which correctly predict no requirement of hospitalization and/or parenteral fluid therapy (dehydration, vomiting or signs of capillary permeability). |
| Estimated within 6 days of presentation |
| Sensitivity of the NS1 detection assays to predict the requirement of hospitalization or parenteral fluid therapy. | Percentage of detection assays which correctly predict the requirement of hospitalization and/or parenteral fluid therapy (dehydration, vomiting or signs of capillary permeability). | Estimated within 6 days of presentation |
| Specificity of the NS1 detection assays to predict the dengue serotype which corresponds to the requirement of hospitalization or parenteral fluid therapy. | Percentage of detection assays which correctly predict the dengue serotype and it's correlation to a requirement of hospitalization and/or parenteral fluid therapy (dehydration, vomiting or signs of capillary permeability). | Estimated within 6 days of presentation |
| D014777 |
| Virus Diseases |
| D018177 | Flavivirus Infections |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006482 | Hemorrhagic Fevers, Viral |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |