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| Name | Class |
|---|---|
| Merck Sharp & Dohme LLC | INDUSTRY |
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This is a single center, observational study of posaconazole PK sampling in lung transplant recipients. The patients enrolled will have up to 6 (3ml) pk samples (a total of 18 ml) and one 10ml blood sample for a total collection of 28ml of blood obtained over the entire study. In addition, the investigators will collect medical record information and any excess BAL samples available during the study (tests done as part of the patient's clinical care and the samples would have been discarded once diagnosis was made).
PK blood samples will be obtained around a clinical dosing of posaconazole
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 'collection of blood samples for PK testing' | Experimental | collection of PK samples around a dosing of Posaconazole |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of blood samples for PK testing | Other | PK samples collected around dosing of posaconazole |
|
| Measure | Description | Time Frame |
|---|---|---|
| measure the levels of posaconazole post dosing | pk samples will be obtained around dosing of medication and then analyzed for posaconazole levels | 24 hours after dosing |
| Measure | Description | Time Frame |
|---|---|---|
| determine the posaconazole concentration within the pulmonary epithelial lining fluid (ELF) and alveolar cells | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ryan Shields, Pharm D | University of Pittsburgh | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UPMC | Pittsburgh | Pennsylvania | 15213 | United States |
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| ID | Term |
|---|---|
| D009181 | Mycoses |
| ID | Term |
|---|---|
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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