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The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| sequential therapy | Active Comparator | first five day amoxicillin+PPI later five day PPI+clarithromycin+metronidazole |
|
| conventional triple thearpy | Active Comparator | PPI+amoxicillin+clarithromycin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sequential versus triple | Drug | sequential: lansoprazole 30mg bid+amoxicillin 100mg bid for first five day lansoprazole 30mg bid+clarithromycin 500mg bid+metronidazole 500mg for 5day conventional tripe lansoprazole 30mg bid+clarithromycin 500mg bid+amoxicillin 1000mg bid |
| Measure | Description | Time Frame |
|---|---|---|
| the eradication rate by urea breath test | to compare the eradication rate (intention-to-treat and per protocol) by urea breath test at least four weeks after treatment | 4-6 week later after completion of therapy |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gil Medical Center | Incheon | South Korea |
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