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| Name | Class |
|---|---|
| Medtronic | INDUSTRY |
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Today patients with a Cardiac Resynchronization Therapy (CRT) indication usually receive 2 ventricular leads, right ventricular (RV) apex and left ventricular (LV) (postero-) lateral, gaining a responder rate of approximately 70%. However, the physiological agitation of the left ventricle takes place over two pathways. Therefore single point stimulation might be insufficient for a dilated, insufficiently and asynchronously contracting left ventricle, resulting in either insufficient or no response to the therapy.
In the "CRT ICD Dual LV" study the patients receive a second LV lead in an anterior vein. When this lead is placed, temporary dual LV stimulation is started. To assess the effectivity of the dual LV lead stimulation intraoperatively a LV dp/dt-pressure measurement is taken. If there is an increase in LV dp/dt, the patients will be stimulated with both leads permanently. If not they will be stimulated conventionally.
The patients participating in this study are monitored for 12 months after implantation.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| second LV lead in CRT | Procedure | second LV lead in CRT |
| Measure | Description | Time Frame |
|---|---|---|
| LV dp/dt pressure during dual LV CRT stimulation vs. conventional biventricular pacing | Implantation with pressure measurement will take place in the first week |
| Measure | Description | Time Frame |
|---|---|---|
| Leftventricular endsystolic volume | 12 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wolfgang Kranig, MD | Contact | +49-5424-6410 | wkranig@schuechtermann-klinik.de | |
| Rainer Grove, MD | Contact | +49-5424-6410 | rgrove@schuechtermann-klinik.de |
| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Kranig, MD | Schuechtermann-Klinik | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Schuechtermann-Klinik | Recruiting | Bad Rothenfelde | Lower Saxony | 49214 | Germany |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D002037 | Bundle-Branch Block |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D006327 | Heart Block |
| D001145 | Arrhythmias, Cardiac |
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| D000075224 |
| Cardiac Conduction System Disease |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |