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There are currently two sensorimotor replacement products which may be of benefit in smoking cessation: de-nicotinised cigarettes (denics) and electronic cigarettes (ECs), and the purpose of this project is to investigate whether these replacements can help to alleviate tobacco withdrawal symptoms in smokers, during a period of abstinence. This project will be separated into two studies, following the same design and procedures.
Study 1 will seek to confirm the importance of sensorimotor cues by comparing the efficacy of a nicotine-free EC in alleviating withdrawal symptoms, to a behavioural distraction tool (e.g. stress ball) which provides no smoking-related cues.
Study 2 will investigate whether sensorimotor replacements which are more proximal to smoking (i.e. Denics), will be more effective in alleviating withdrawal symptoms than a replacement which only delivers some of the conditioned sensorimotor cues (i.e. ECs).
The investigators hypothesise that the EC will be more effective at reducing withdrawal symptoms compared to the stress ball in Study 1. In Study 2, it is hypothesised that the Denic will be more effective than the EC.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stress Ball | Active Comparator | This is the active comparator for study 1 |
|
| De-nicotinised Cigarette | Experimental | This will be the experimental arm for study 2 |
|
| Nicotine-free Electronic Cigarette (1) | Experimental | This will be the experimental arm for study 1 |
|
| Nicotine-free Electronic Cigarette (2) | Active Comparator | This will be the active comparator for study 2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress Ball vs Nicotine-free E-Cigarette | Behavioral | In a cross over design, participants will be randomly allocated to:
One week later participants will complete the other arm. |
| Measure | Description | Time Frame |
|---|---|---|
| Urge to smoke at 10 minutes post product use | Urges to smoke will be measured at 10 minutes after use of products | 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Tobacco withdrawal symptom ratings over 1 hour | Change withdrawal ratings one hour after product use | 1 hour |
| Tobacco withdrawal symptom ratings over one day | Change in tobacco withdrawal symptom ratings over a day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dunja Przulj | Queen Mary University of London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tobacco Dependence Research Unit | London | E1 2JH | United Kingdom |
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|
| Nicotine-free E-Cigarette vs De-nicotinised Cigarette | Behavioral | In a cross over design, participants will be randomly allocated to:
One week later participants will complete the other arm. |
|
| 1 day |