To identify problems/questions about following items in the clinical practice using Betaferon

1. Unknown adverse event (especially serious adverse event)
2. Identification of adverse event occurred in the real practice
3. Factors that may affect the safety of drug
4. Factors that may affect the effectiveness of the drug

Inclusion Criteria:

• Patients with diagnosis of MS or CIS and decision taken by the physician to prescribe Betaferon
• Patients who have not participated in Betaferon regulatory Post Marketing Surveillance before.

Exclusion Criteria:

• Exclusion criteria must be read in conjunction with local product information

Patients with diagnosis of Multiple Sclerosis or Clinically Isolated Syndrome who have been or will be treated with Betaferon.