HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles

Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing Intrauterine Insemination: a Prospective Randomized Study.

We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.

Inclusion Criteria:

• age ≤ 36 years,
• regular menstrual cycles,
• body mass index (BMI) between 18 and 29 kg/m²,
• basal levels of FSH (≤ 12 IU/l),
• estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle).
• The use of donor sperm was also accepted as inclusion criteria.

Exclusion Criteria:

• PCOS
• endometriosis