Diclofenac add-on to Treatment as Usual for Suicidal Patients

"Antiinflammatoriska läkemedels Effekt för Att Minska Suicidalitet Hos Deprimerade Patienter Som Nyligen Har Gjort självmordsförsök"

The purpose of this study is to determine whether diclofenac is effective in the treatment of depressed patients with a recent suicide attempt.

The study will start with a feasibility study including treatment of 10 patients with diclofenac.

Inclusion Criteria:

• Depressive disorder
• Montgomery Asberg Rating Scale Score more than 20 p.
• Recent suicide attempt (Treated as inpatient due to a recent suicide attempt)
• Informed consent
• Competence to give informed consent

Exclusion Criteria:

• Pregnancy
• Breastfeeding
• Serious somatic disease e.g. serious heart, vascular, hepatic, kidney, pulmonary, intestinal, endocrine, haematological or neurological diseases
• Ongoing substance abuse
• Schizophrenia or other psychotic disorders
• Ongoing psychosis
• Risk factors for cardiovascular events
• Ulcer or gastrointestinal bleeding
• Ongoing Electroconvulsive therapy
• Previous allergic reaction to NSAID, acetylsalicylic acid, sulfonamides or the diclofenac or sugar pill content
• Galactose intolerance, lactase deficiency or glucose-galactose malabsorption
• Ongoing treatment with warfarin or other anticoagulants
• Ongoing treatment with ACE inhibitors or angiotensin II antagonists Ongoing treatment with drugs known to effect the immune system Ongoing treatment with rifampicin, carbamazepine or barbiturates