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Study hypothesis: Is Alhydran gel-cream as efficient as silicone gel for skin occlusion and hydration?
For this study 16 volunteers and ten patients with healed full thickness burns will be included.
After a short period of acclimatization four test areas will be determined. For healthy volunteers the standard zones are located on the inner forearm, two on each forearm.
For patients with healed burns the 4 test zones are located on either the healed donor site or the healed skin grafted area.
In each test zone baseline measurements will be taken before application of the products.After application of the three silicone gels and the hydrating gel cream the trans epidermal water loss (TEWL) and the moisture content of the stratum corneum will be measured by using the TEWAmeter®TM300 and the Corneometer® CM825 (Courage & Khazaka).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients and healthy volunteers | Experimental | Patients with healed full thickness burns and healthy volunteers will be included in the study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dermatix | Drug | 1 application of Dermatix |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The occlusive and hydrating capacity of the products. | Measurements will be done by using the TEWAmeter® for measurement of the Trans Epidermal Waterloss and the Corneometer® 825CM for measurement of the moisture content of the stratum corneum (Courage & Khazaka). For this study no risk factors are determined. | 1 hour after application |
| Measure | Description | Time Frame |
|---|---|---|
| The occlusive and hydrating capacity of the products. | Measurements will be done by using the TEWAmeter® for measurement of the Trans Epidermal Waterloss and the Corneometer® 825CM for measurement of the moisture content of the stratum corneum (Courage & Khazaka). For this study no risk factors are determined. | 2 hours after application |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Affiliation | Role |
|---|---|---|
| S. Monstrey, MD PhD | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Ghent | 9000 | Belgium |
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| Label | URL |
|---|---|
| Related Info | View source |
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| Kelocote |
| Drug |
1 application of Kelocote |
|
| BAP scar gel | Drug | 1 application of BAP scar gel |
|
| Alhydran | Drug | 1 application of Alhydran |
|
| Bap Scar Care T | Drug | 1 application of BAP Scar Care T |
|
| Bap Scar Care S | Drug | 1 Application of Bap Scar Care S |
|
| Mepiform | Drug | 1 application of Mepiform |
|
| Scar Ban Elastic | Drug | 1 application of Scar Ban Elastic |
|
| The occlusive and hydrating capacity of the products. |
Measurements will be done by using the TEWAmeter® for measurement of the Trans Epidermal Waterloss and the Corneometer® 825CM for measurement of the moisture content of the stratum corneum (Courage & Khazaka). For this study no risk factors are determined. |
| 3 hours after application |
| ID | Term |
|---|---|
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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