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The objective of the study is to investigate whether peri-operative symbiotic treatment could reduce the risk of postoperative infections in patients undergoing elective colorectal surgery. This study was also designed to assess the risk-adjusted incidence and predictors of surgical site infections.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Symbiotic | Experimental | Symbiotic is a combination of prebiotics and probiotics that is designed to have synergistic or additive effects benefiting the host |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Symbiotic | Biological | Oral symbiotic every 8 h since 2 days before operation; Symbiotic resumes postoperatively on day +2 until day +4 for a total of 4 d of treatment (12 doses). |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of post-operative infection after elective colorectal surgery among patients with and without pre-operative symbiotic conditioning. | 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of postoperative infection including surgical site infections (SSIs) and distant-site infections after elective colorectal surgery in patients whether or not receiving pre-operative symbiotic conditioning. | 15 months |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D013530 | Surgical Wound Infection |
| ID | Term |
|---|---|
| D014946 | Wound Infection |
| D007239 | Infections |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |