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| Name | Class |
|---|---|
| Ajinomoto USA, INC. | INDUSTRY |
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This study will test whether regular consumption of Monosodium Glutamate (MSG) immediately prior to each of the three major meals (breakfast, lunch, dinner) inhibits body weight and fat regain following a period of moderate, yet clinically significant weight loss.
The proposed study enables us to assess the long term effects of consuming MSG on body weight regain following weight loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Broth- NaCl | Placebo Comparator | Sodium chloride containing broth matched for sodium content to the MSG broth |
|
| Broth- MSG | Active Comparator | MSG containing broth with the same sodium content as the placebo comparator. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Broth | Other | 200 mL of sodium chloride containing broth, consumed three times per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in body weight | Subjects will have their body weight measured to determine the effect of MSG on body weight regain following weight loss. | weeks 11, 12, and 25 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in body fat | Volunteers will have their body fat measured by DEXA (Dual X-ray Absorptiometry) to determine the effect of MSG on body fat regain following weight loss. | weeks 11 and 25 |
| Change in eating behavior |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kevin Laugero, PhD | WHNRC, ARS, University of California Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Western Human Nutrition Center, University of California Davis | Davis | California | 95616 | United States |
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| Label | URL |
|---|---|
| USDA Western Human Nutrition Research Center | View source |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D015430 | Weight Gain |
| D005518 | Food Preferences |
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Broth |
| Other |
200 mL of MSG containing broth consumed three times per day |
|
The effect of MSG on eating behavior will be measured using questionnaires, sensory evaluation testing, stress responsivity, and liking and wanting tests, and appetite assessments.
| weeks 11, 12 and 25 |
| Change in resting energy expenditure | The effect of MSG on resting energy expenditure will be measured using respiratory gas exchange using a metabolic cart system. | weeks 11, 12, and 25 |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |
| D001519 | Behavior |
| D001522 | Behavior, Animal |