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This study is designed to assess the pathophysiology of ST by studying the main procedural and anatomical factors involved in the genesis of ST such as those related to stent and the vascular wall, as well as to the individual platelet residual reactivity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stent Thrombosis | Experimental | Consecutive patients with stent thrombosis with stent strut assessment by OCT |
|
| Controls | Active Comparator | Control subjects without stent thrombosis from the RHR OCT database |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OCT guided PCI | Device | OCT guided PCI. Only thrombectomy in case of negative OCT findings (other than uncovered struts). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of uncovered stent struts | The percentage of uncovered stent struts by OCT in patients with subacute stent thrombosis (either DES and BMS) and the percentage of uncovered stent struts in patients with late (after one month) and very late thrombosis of DES. | After thrombectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of malapposed stent struts | The percentage of malapposed stent struts by OCT in patients with subacute thrombosis of DES and BMS and the percentage of malapposed stent struts by OCT in patients with late and very late thrombosis of DES. | After Thrombectomy |
| Percentage of patients with high residual platelet reactivity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Antoniucci, MD | Careggi Hospital, Division of Invasive Cardiology | Study Chair |
| Francesco Prati, MD | Rome Heart Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Careggi Hospital, Department of Hearth and Vessels | Florence | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24384290 | Derived | Parodi G, La Manna A, Di Vito L, Valgimigli M, Fineschi M, Bellandi B, Niccoli G, Giusti B, Valenti R, Cremonesi A, Biondi-Zoccai G, Prati F. Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism Of Stent Thrombosis (MOST) study. EuroIntervention. 2013 Dec;9(8):936-44. doi: 10.4244/EIJV9I8A157. |
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| ID | Term |
|---|---|
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| OCT guided medical therapy | Drug | OCT guided medical therapy. Tailored antiplatelet therapy. |
|
The percentage of patients with residual platelet reactivity (RPR) to ADP and arachidonic acid identified by values ≥ 240 P2Y12 reaction units (PRU) and ≥ 550 aspirin reaction units (ARU), respectively,. during aspirin and clopidogrel therapy or in which one or both the antiplatelet drugs have been interrupted. |
| Baseline |