Safety/Efficacy Study: OPA-6566 Ophthalmic Solution in Subjects With Primary Open-Angle Glaucoma or Ocular Hypertension

An Investigator-Masked, Dose-Escalation Study to Determine the Safety, Tolerability, Pharmacokinetics, and Efficacy of OPA-6566 Ophthalmic Solution in Subjects With Primary Open-Angle Glaucoma or Ocular Hypertension

This is a study of the safety, tolerability, pharmacokinetics (measurement of drug levels in the blood), and intraocular pressure lowering effects of OPA-6566 ophthalmic solution in subjects with primary open-angle glaucoma or ocular hypertension.

Inclusion Criteria:

• diagnosis of bilateral primary open-angle glaucoma
• diagnosis of ocular hypertension as defined in the protocol

Exclusion Criteria:

• any form of glaucoma other than primary open-angle glaucoma in either eye
• other ocular conditions as defined by the protocol