German Diabetes-Diet-Intervention and Energy Restriction-Trial (DDIET)

Short Term Diet Intervention in Newly Diagnosed Type 2 Diabetes. a Randomised, Multicentric, Controlled, Clinical Trial

Diet intervention according to the German Diabetes Risk Score in newly diagnosed type 2 diabetes.

This study aims to explore the effect of diet lacking red meat, but containing increased fibers and coffee (verum) versus standard recommendation (control) in a multicenter setting.

This study is a randomised, multicenter controlled trial Our Aim is to test the effects of an 8-week diet lacking red meat, containing increased fibers and coffee (verum) versus standard recommendation (control)in a multicenter setting.

We are expecting that the verum diet will improve insulin sensitivity and insulin secretion due to reductions in visceral and hepatic fat along with improved adipocyte cytokine secretion profiles

Inclusion Criteria:

• Type 2 diabetic patients
• disease duration for five years or less,
• age of 69 years or less,
• body mass index of 30 kg/m2 or more,
• hemoglobin A1c of 5,5 % to 9%
• patient should be on standard diet or metformin +/- acarbose monotherapy
• patient should be without exclusion criteria for coffee consumption

Exclusion Criteria:

• disease duration more than five years,
• age of > 69 years,
• body mass index of < 30 kg/m2,
• hemoglobin A1c < 5,5 % or > 9%
• if patient becomes insulin therapy
• if patient has exclusion criteria for coffee consumption
• if patient is non-compliant with study protocol
• if patient is pregnant
• if patient has acute infection
• if patient has anaemia
• if patient has malignancies
• if patient has autoimmune or immune compromising diseases including HIV/AIDS
• if patient has psychiatric diseases or addiction