Effect Of CP-690,550 On The Pharmacokinetics Of Metformin In Healthy Volunteers

A Phase 1, Open Labeled, Fixed Sequence Study To Estimate The Effect Of CP-690,550 On The Pharmacokinetics Of Metformin In Healthy Volunteers

This study will evaluate the potential effect of CP 690,550 on the pharmacokinetics of metformin, a probe drug for organic cationic transport.

Inclusion Criteria:

• Adult healthy male and/or female (of non child bearing potential) subjects.

Exclusion Criteria:

• Subjects with clinically significant systemic and laboratory abnormalities.
• Subjects with clinically significant infections within the past 3 months.
• Women of child-bearing potential.