Longitudinal Evaluation Study of Vaginal Stenosis With and Without Pelvic Radiation Therapy

Prospective Longitudinal Evaluation of Vaginal Stenosis and Sexual Function in Women With Pelvic Malignancies Treated With and Without Pelvic Radiation Therapy

This study evaluates the effects of treatment with a vaginal dilator to reduce vaginal stenosis in women receiving pelvic radiation therapy for pelvic malignancies.

Vaginal stenosis can occur as a result of treatment for pelvic malignancies. Women receiving pelvic radiation therapy using a vaginal dilator 5-7 times per week will have less vaginal stenosis than women using a vaginal dilator fewer times or not at all.

Inclusion Criteria:

• Pre and post menopausal women undergoing definitive (not palliative) treatments for a pelvic malignancy, including rectal, endometrial, cervical, or anal canal carcinoma.
• Treatments include radiation therapy, chemotherapy, surgery, or a combination of therapies.
• May have early-stage or locally advanced (node positive) disease.
• Male partners of the female subjects are also consented for this study.

Exclusion Criteria:

• Subject may not have evidence of metastatic disease.
• Prior pelvic radiation therapy
• Prior hysterectomy (not for current diagnosis)
• Diagnosis of prior malignancy, except non-melanoma skin cancer.