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The purpose of this study is to evaluate the efficacy of intravitreal triamcinolone and retrobulbar chlorpromazine as alternatives in the management of ocular pain in blind eyes.
The management of chronic eye pain is a constant challenge to ophthalmology. Treatment varies with the intensity of pain, and topical eye drops and contact lens therapy are effective in many patients. In refractory cases, and without vision, surgical removal of the eye through enucleation is considered classical therapy. As less invasive alternatives we have cyclodestruction and neurolytic drug injection in order to promote analgesia for a prolonged period.
The purpose of this study is to evaluate the efficacy of intravitreal triamcinolone and retrobulbar chlorpromazine as alternatives in the management of This is a prospective study of patients with blind painful eyes not responsive to topical treatment and with no indication for evisceration seen at the Department of Ophthalmology, Hospital Governador Celso Ramos (HGCR) in 2010.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intravitreal Triamcinolone | Active Comparator | Patients with phthisis bulbi received 0,3ml intravitreal triamcinolone injection |
|
| Retrobulbar Chlorpromazine | Active Comparator | Patients with refractory glaucoma and blind painful eye were submitted to 2,5mL Chlorpromazine retrobulbar injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triamcinolone | Drug | 0,3mL intravitreal injection of Triamcinolone, single dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Pain intensity | Pain was measured asking the patient to graduate it in a scale from 0 to 10, 0 being no pain, 10 being the worst pain patient has experienced in life | 0, 1 month, 3 months, 6 months after procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Use of eyedrops before and after drug injection | Patient use of eyedrops before and after the procedure (yes or no) | 0, 1 month, 3 months, 6 months |
| Changes in Intraocular pressure (IOP) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Deborah C Ribas, MD | Hospital Governador Celso Ramos | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Governador Celso Ramos | Florianópolis | Santa Catarina | 88015270 | Brazil |
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| Chlorpromazine | Drug | 2,5mL Chlorpromazine retrobulbar injection, single dose |
|
|
IOP was measured at all times of patient evaluation
| 0, 1 months, 3 months, 6 months |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D014221 | Triamcinolone |
| D002746 | Chlorpromazine |
| ID | Term |
|---|---|
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D010640 | Phenothiazines |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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