The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care

The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care: a Randomized, Open, Cross-over Study

The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.

Inclusion Criteria:

• According to RIFLE score, patient is stage 'F'
• The patient must be insured or beneficiary of a health insurance plan
• The patient meets at least one of the following criteria:
• metabolic acidosis (pH < 7.2), excluding keto-acidosis
• plasma urea > 25 mmol/l
• hyper-hydration is not controlled by diuretics

Exclusion Criteria:

• Chronic, terminal renal insufficiency with dialysis
• The patient is under judicial protection, under tutorship or curatorship
• Suspect hyperkaliemia (Kaliemia > 6.5 mmol/l with electrocardiographic effects)
• Intoxications treated via dialysis
• Pregnant, lactating, parturient women
• Medical indication for localized citrate anticoagulation
• dialysis of less than 12 h
• patient or representative refuses to participate