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20131209 Regulatory authorization is currently blocked at the ANSM.
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The primary objective of this study is to evaluate the reproducibility of a method of measuring blood flow rates to the tracheo-bronchial mucosa using diluted dimethyl ether as a tracer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Experimental | All patients included in this study according to stated inclusion and exclusion criteria. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood flow to the tracheo-bronchial mucosa | Biological | Measurement of blood flow to the tracheo-bronchial mucosa via differential absorption of diluted dimethyl ether tracer gas. |
| Measure | Description | Time Frame |
|---|---|---|
| The reproducibility of two measures of Qaw at a five minute interval | Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME*alpha*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml). | Five minutes |
| Measure | Description | Time Frame |
|---|---|---|
| The time necessary to complete one measure of Qaw (minutes) | Qaw = blood flow measured in the tracheobronchial mucosa | Day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charles Le Merre, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
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