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| Name | Class |
|---|---|
| Region of Southern Denmark | OTHER |
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The aim of the study is to evaluate the pharmacodynamic impact of metformin in healthy Caucasian volunteers with and without single polymorphisms M420del or R61C in OCT1, thus the study hypothesis is that metformin only affect the hepatic gluconeogenesis in healthy volunteers with functional OCT1-transporters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Homozygote wildtype OCT1 | Active Comparator |
| |
| Heterozygote OCT1 | Active Comparator |
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| Homozygote OCT1 variant | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metformin | Drug | The study was designed as a randomized, cross-over trial with a washout period of at least 4 weeks between the phases. In both phases, the volunteers fasted for 42 h. This was done in order to include an evaluation of the pharmacodynamic effect of metformin on the glucose production in fasting healthy volunteers. |
| Measure | Description | Time Frame |
|---|---|---|
| Endogenous glucose production | 48 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mette Marie H Christensen, MD | Department of Public Health, Clinical Pharmacology, University of Southen Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinical pharmacology, Institute og public health, University of Southern Denmark | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41928890 | Derived | Kolnes KJ, Moller PM, Kruse R, Christensen MMH, Kjobsted R, Hey-Mogensen M, Andersen B, Handberg A, Hojlund K. Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans. Front Endocrinol (Lausanne). 2026 Mar 18;17:1797525. doi: 10.3389/fendo.2026.1797525. eCollection 2026. | |
| 26271344 | Derived |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008687 | Metformin |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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| Christensen MM, Hojlund K, Hother-Nielsen O, Stage TB, Damkier P, Beck-Nielsen H, Brosen K. Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial. Diabetologia. 2015 Nov;58(11):2494-502. doi: 10.1007/s00125-015-3733-2. Epub 2015 Aug 14. |
| D004700 | Endocrine System Diseases |