Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention

Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention

To investigate the predictive value of the contrast media volume to creatinine clearance (V/CrCl) ratio for the risk of contrast-induced nephropathy (CIN) (i.e., within 48-72 h) and to determine a relatively safe V/CrCl cut-off value to avoid CIN in patients following PCI

contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after unselective PCI. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of CIN was assessed using multivariate logistic regression.

Inclusion Criteria:

• patients who agreed to stay in the hospital for 2-3 days after percutaneous coronary intervention
• provided written informed consent
• Creatinine Clearance:15-60ml/min

Exclusion Criteria:

• pregnancy
• lactation
• intravascular administration of an contrast medium within the previous seven days
• treatment with metformin
• aminoglycosides
• N-acetylcysteine (NAC)
• nonsteroidal anti-inflammatory drugs within the previous 48 h
• intake of nephrotoxic drugs within the previous seven days
• history of serious reactions to contrast mediums
• severe concomitant disease
• renal transplantation , or end-stage renal disease necessitating dialysis patients who died during percutaneous coronary intervention