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The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| elderly | Experimental | subjects are at least 60 years old (with no upper age limit), receiving 2 immunisations with IXIARO |
|
| young | Experimental | subjects 18 to 40 years old, receiving 2 immunisations with IXIARO |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IXIARO | Biological | 2 immunizations (0,5ml) with a 28 day interval |
|
| Measure | Description | Time Frame |
|---|---|---|
| cellular immunity (cytokine production upon stimulation with Japanese Encephalitis (JE) Virus Antigen) 7 days after the 2. JE-vaccination | 7 days after the 2 JE vaccinations |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ursula Wiedermann, MD, PhD | Institute of Specific Prophylaxis and Tropical medicine, Vienna | Principal Investigator |
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