Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine

Characterisation of Cellular and Humoral Immunity in Elderly People After Immunization With a Purified, Inactivated Japanese Encephalitis Vaccine.

The aim of this project is to investigate humoral and cellular immune responses before and after immunisation with the Japanese encephalitis vaccine IXIARO in subjects above 60 years of age and 18-40 years old subjects.

Inclusion Criteria:

• adults (18-40 years old)
• adults (≥60 years),
• both sexes
• willingness to sign written informed consent form

Exclusion Criteria:

• age below 18 years or between 41-59 years old
• status post japanese encephalitis, tick born encephalitis (TBE), dengue, yellow fever or West Nile virus infection
• previous immunization against yellow fever, japanese encephalitis (dengue or WNV)
• current acute infection (body temperature above 37,9°C)