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The Activity of Indoleamine 2,3-dioxygenase in patients with Chronic Lymphocytic Leukemia (CLL) is studied.
The Activity of Indoleamine 2,3-dioxygenase in patients with Chronic Lymphocytic Leukemia (CLL)is studied in patients and healthly controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CLL-patients | |||
| Controls |
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| Measure | Description | Time Frame |
|---|---|---|
| IDO activity and expression measured by kynurenine/tryptophan ratio in serum and by PCR in peripheral blood mononuclear cells. | Indoleamine 2,3 -dioxygenase (IDO) activity in patients with CLL was measured by the serum kynurenine/tryptophan (kyn/trp) ratio and - the expression of INDO (encoding IDO enzyme) and INDOL1 (encoding IDO2 enzyme) genes in peripheral blood mononuclear cells via TaqMan real-time PCR. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with CLL
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| Name | Affiliation | Role |
|---|---|---|
| Marjatta Sinisalo, MD, PhD | Tampere University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tampere university Hospital | Tampere | 33521 | Finland |
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Ido expression