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The purpose is to assess the response of add-on therapy, based on CGI-I scale, at 4 weeks, in patients with MDD who had an inadequate disease control with antidepressant medication.
A cross-sectional observational study to describe treatment management of patients with Major Depressive Disorder (MDD) and inadequate response to antidepressants in Greece
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Inpatients and outpatients diagnosed with major depressive disorder as per the DSM-IV criteria who had poor disease control during antidepressant treatment and have completed 4 weeks of add-on drug therapy at enrolment in the study. The percentage of patients with CGI-I score ≤ 2 at study Visit (4 weeks after the commencement of add-on treatment). |
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| Measure | Description | Time Frame |
|---|---|---|
| To assess the response of additional therapy by assessment of percentage of patients with CGI-I score ≤ 2 | At week 4 after the commencement of add-on therapy |
| Measure | Description | Time Frame |
|---|---|---|
| Number of consecutive treatments administered for the management of the current MDD episode until the commencement of adjunctive (add-on) medication. | At week 4 after the commencement of add-on therapy | |
| Percentage of patients (n, %) with MADRS score ≤ 10 at week 4 following the onset of adjunctive medication |
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Inclusion Criteria:
Exclusion Criteria:
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Psychiatric patients
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| Name | Affiliation | Role |
|---|---|---|
| Panagiotis Pontikis | Marketing Company Medical and Regulatory Affairs Director, AstraZeneca S.A. Greece | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Arta | Artas | Greece | |||
| Research Site |
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| At week 4 following the onset of add-on medication |
| Percentage of patients (n,%) with a change (decrease) in MADRS score be ≥ 50% | At week 4 following the initiation of add-on drug therapy. |
| Athens |
| Attica |
| Greece |
| Research Site | Chaïdári | Attica | Greece |
| Research Site | Dafni | Attica | Greece |
| Research Site | Glyfada | Attica | Greece |
| Research Site | Kifissia | Attica | Greece |
| Research Site | Koropí | Attica | Greece |
| Research Site | Marousi | Attica | Greece |
| Research Site | Nea Makri | Attica | Greece |
| Research Site | Peristeri | Attica | Greece |
| Research Site | Petroúpolis | Attica | Greece |
| Research Site | Rhodes | Dodekanese | Greece |
| Research Site | Agrinio | Etoloacarnania | Greece |
| Research Site | Lamia | Fhiotida | Greece |
| Research Site | Heraklio | Heraklio | Greece |
| Research Site | Ioannina | Ioanninon | Greece |
| Research Site | Kalamata | Kalamata | Greece |
| Research Site | Karditsa | Karditsa | Greece |
| Research Site | Kavala | Kavala | Greece |
| Research Site | Larissa | Larissa | Greece |
| Research Site | Ag. Nikolaos | Lasithiou | Greece |
| Research Site | Pátrai | Patras | Greece |
| Research Site | Aigáleo | Piraeus | Greece |
| Research Site | Serres | Serres | Greece |
| Research Site | Thessaloniki | Thessaloniki | Greece |
| Research Site | Trikala | Trikala | Greece |
| Research Site | Thebes | Viotia | Greece |
| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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