Multiple Ascending Dose Study of GLPG0492 in Healthy Subjects

Double Blind, Placebo Controlled Dose Ranging Study for the Assessment of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses of GLPG0492 in Healthy Subjects

The purpose of the study is to evaluate the safety and tolerability of multiple ascending oral doses (MAD) of GLPG0492 given to healthy subjects for 14 days compared to placebo, and to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of GLPG0492 after multiple oral administrations.

Inclusion Criteria:

• healthy male, age 18-50 years
• body mass index (BMI) between 18-29.9 kg/m², inclusive.
• normal values of testosterone (2.49-8.36 ng/mL) and LH (1.7-8.6 U/L)

Exclusion Criteria:

• smoking
• drug or alcohol abuse
• hypersensitivity to any of the ingredients of the study drug