Japanese Phase 1 Multiple Ascending Dose (MAD) Study

Randomized, Placebo-Controlled, Double-Blind, Ascending Multiple-Dose Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BMS-820836 in Healthy Japanese Subjects and Japanese Patients With Depression

The purpose of this clinical study is to assess the safety and tolerability of multiple oral doses of BMS-820836 in healthy Japanese subjects and Japanese patients with depression.

Inclusion Criteria:

• Healthy Japanese subjects and Japanese patients with depression (Hamilton Rating Scale for Depression (HAM-D) ≥ 14), ages 20 to 55 years.

Exclusion Criteria:

• Any significant acute or chronic medical illness.
• Non-compliance, or overall not suitable as determined by the investigator.
• History of, or current clinically significant psychiatric disorders or illnesses, substance abuse or dependence.