The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive hearing loss in both ears due to autoimmune inner ear disease (AIED).

Sudden out-of-hospital cardiac arrest (OOH-CA) remains a significant cause of death, in spite of recent declines in overall mortality from cardiovascular disease. Existing methods of emergency resuscitation are inadequate due to time delays inherent in the transport of a trained responder with defibrillation capabilities to the side of the OOH-CA victim. Existing Emergency Medical Services (EMS) systems typically combine paramedic Emergency Medical Technician (EMT) services with some level of community involvement, such as bystander cardiopulmonary resuscitation (CPR) training. Some communities include automated external defibrillators (AEDs) at isolated sites or in mobile police or fire vehicles. A comprehensive, integrated community approach to treatment with AEDs would have community units served by these volunteer non-medical responders who can quickly identify and treat a patient with OOH-CA. Such an approach is termed Public Access Defibrillation (PAD).

Inclusion Criteria:

• patients with pancreatic carcinomas after surgery (resection or exploration)
• given consent

Exclusion Criteria:

• acute infection
• pain
• no mobility or ability for walking or standing
• severe neurological disorders (apoplex, morbus Parkinson, paresis of the lower extremeties)
• severe cardiac or cardiovascular diseases (z.B. heart insufficiency NYHA III, myocardial infarction <3 months)
• rhytmical disorders, that contraindicate ergospirometric examinations
• cardiac therapy with digitalis pharmacy
• unclear syncopes
• severe pulmonal insufficiency
• renal insufficiency (GFR < 30% at Krea >3 mg/dl)
• synchronous participation in an other clinical trial