ACAM2000® Myopericarditis Registry

ACAM2000® Myopericarditis Registry

The purpose of this registry is to study the natural history of vaccination-related myocarditis and pericarditis and to assess possible risk factors for these conditions.

Primary Objective:

- To document the natural history of confirmed, probable, suspected, and subclinical myocarditis and pericarditis (myopericarditis) following ACAM2000® vaccination.

Other Pre-defined Objective:

- To look for potential predictive factors for the prognosis of myopericarditis following ACAM2000® vaccination.

All participants will have received previous vaccination with ACAM2000 but will not receive any vaccination as part of the registry. All participants enrolled in the registry will be followed for 2 up to 5 years (depending on whether there are persisting signs and symptoms of myopericarditis).

Inclusion Criteria:

• Individuals who are current or former members of the active duty, Reserve, or National Guard, from any branch of service
• Documented vaccination with ACAM2000® vaccine
• Meet one of the case definitions for suspect, probable, confirmed or subclinical myopericarditis.

Exclusion Criteria:

• Individuals not meeting at least one of the case definitions for myopericarditis will not be entered into the Registry.