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| Name | Class |
|---|---|
| Dairy Management Inc. | INDUSTRY |
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Does the consumption of dairy foods reduce the rate of bone loss in older women more than calcium and vitamin D supplements.
Research indicates that bone health is dependent on multiple nutrients, not just calcium and vitamin D, leading to the conclusion that calcium from sources that include other bone enhancing nutrients may be more effective in maintaining bone integrity than calcium and vitamin D supplements. Several studies have examined the effects of calcium intake from dairy foods on different indicators of bone health. Reducing the rate of bone loss in postmenopausal women can reduce the risk of osteoporosis related fractures. Therefore we propose to study the effectiveness of 4 servings of milk and yogurt per day for 42 days compared to calcium and vitamin D supplements for 42 days to reduce calcium loss from the skeleton in post menopausal women. Postmenopausal women, approximately 50-65 years of age, will be studied. Each volunteer will receive both interventions in a cross-over design, in random order, separated by a 42 day washout period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Experimental | Four servings of dairy foods per day for 42 days, followed by washout for 42 days, followed by dietary supplements for 42 days |
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| Arm 2 | Experimental | Dietary Supplements for 42 days, followed by washout for 42 days, followed by 4 servings of dairy foods for 42 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intervention I | Other | Four servings of dairy foods (milk and yogurt) per day for 42 days. |
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| Measure | Description | Time Frame |
|---|---|---|
| Ratio of 41Ca/40Ca excreted in urine | Subjects will be asked to collect 24 hour urine samples to establish each individual's kinetic profile of Ca excretion and to measure the effectiveness of the interventions. | Days 0, 90, 120, 150, 180, 187, 194, 201, 208, 215, 222, 229, 236, 243, 250, 257, 264,271, 278, 285, 292, 299, and 306 of the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marta Van Loan, PhD | WHNRC, ARS, University of California Davis | Principal Investigator |
| Marjorie Garrod, Ph.D. | USDA, ARS, WHNRC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Western Human Nutrition Research Center | Davis | California | 95616 | United States |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D001851 | Bone Diseases, Metabolic |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008722 | Methods |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
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| Intervention II | Dietary Supplement | 1200 mg of supplemental calcium and 400 IU of vitamin D3 for 42 days |
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