"ESTIMATION Study" for Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction

Endocardial Mesenchymal Stem Cells Implantation in Patients After Acute Myocardial Infarction

The investigators hypothesised that endocardial stem cells implantation following after percutaneous coronary intervention (PCI) could reduce the scar formation and increase reverse remodeling in patients with primary acute myocardial infarction.

Inclusion Criteria:

• Patients with acute Q-wave myocardial infarction after thrombolitic therapy during 6-36 hours from the onsent of signs
• Oclusion or significant stenosis of infarct-related left anterior descending artery (LAD)
• Left ventricle ejection fraction (LVEF) < 50% measured by Echo

Exclusion Criteria:

• Thrombolysis of pyrrolase or streptokinase
• Surgical unsignificant stenosis of LAD
• Indications for CABG
• Cardiogenic shock
• Uncontrolled hypertension
• Thrombocytopenia
• Ongoing bleeding
• Anemia < 100 g/l
• Oncology
• Patients, who required anticoagulation therapy at the time of inclusion
• Obesity, BMI>40
• Severe comorbidities
• Unwillingness to participate