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The purpose of this study is to quantify the tidal volume generated by the pressure release immediately following the application of pressure to the chest.
Airway management in the pediatric population differs from the adult population because of differences in their respiratory physiology and anatomy. For example the oxygen consumption is about three times higher in children as compared to adults; therefore, if there is a problem ventilating a child there is a higher impact on oxygen delivery and oxygen reserve. Current guidelines recommend that in respiratory emergencies where one "cannot ventilate and cannot intubate" that a cricothyroidectomy (insertion of a needle through the cricothyroid membrane in the neck) be performed. This procedure is very invasive and difficult to perform, especially in a small child. Since timing and simplicity are essential to successful airway management it is hypothesized that the investigators could utilize the physiological principles behind breathing to ventilate these children using the release of applied pressure to their chest. During, inspiration, the vertical and transverse dimensions of the thorax are increased, generating a negative pressure between the intrapleural space and the chest wall, allowing for air to be drawn into the lungs. As children have a very compliant rib cage one of the theoretical ways to improve lung inflation is to apply external pressure on the chest. The intrathoracic pressure increases above atmospheric pressure and air preferentially flows out of the lungs according to the pressure gradient. When the pressure is released and the chest recoils passively, a negative intrathoracic pressure is generated, which allows for air to flow into the lungs according to the pressure gradient created. If a sufficient tidal volume is generated by the release of pressure from the chest this could potentially become a simple, non-invasive, life-saving technique in children with difficult airways. By adapting the principles described above, it is possible that tidal volume and therefore, gas exchange can take place on release of the pressure applied to the chest.
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| Measure | Description | Time Frame |
|---|---|---|
| Tidal volume (mL), as displayed by the Draeger Narkomed 6400 Anesthesia Machine, after release of manual chest compression | One tidal volume is displayed on the Draeger machine immediately after the manual release of chest compression. This outcome is recorded 3 times in each patient after fast manual compressions (1-2 seconds each), with the process performed while the patient is both bag-mask ventilated and intubated. | After induction of general anesthesia and until completion of surgery (within an average time of 30 mins to 4 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| Force of compression (kg), as displayed by the Lafayette Manual Muscle Tester, measured during each manual chest compression | after induction of general anesthesia and during surgery (between 30 mins and 4 hours) |
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Inclusion Criteria:
Exclusion Criteria:
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This is a prospective, cohort study with a sample size of approximately 100 pediatric patients. The population will be stratified equally into the following age groups: neonate (0-28 days or 44 post-conceptual weeks), infants (>1-12 months), toddlers (>12months-3 years), children (>3-8 years), pre-teen (>8-13 years) and adolescent (>13 years).
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| Name | Affiliation | Role |
|---|---|---|
| Ban Tsui, M.D., M.Sc. | Department of Anesthesiology and Pain Medicine, University of Alberta | Principal Investigator |
| Viv Ip, M.D. | Department of Anesthesiology and Pain Medicine University of Alberta | Study Director |
| Sara Horne, B.Sc.(Hons) | Department of Anesthesiology and Pain Medicine University of Alberta | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stollery Children's Hospital | Edmonton | Alberta | T6G 2B7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9794863 | Background | Williams AJ. ABC of oxygen: assessing and interpreting arterial blood gases and acid-base balance. BMJ. 1998 Oct 31;317(7167):1213-6. doi: 10.1136/bmj.317.7167.1213. No abstract available. | |
| 662489 | Background | Adler SM, Wohl ME. Flow-volume relationship at low lung volumes in healthy term newborn infants. Pediatrics. 1978 Apr;61(4):636-40. |
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| ID | Term |
|---|---|
| D001049 | Apnea |
| D053120 | Respiratory Aspiration |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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| 19564271 | Background | Braga MS, Dominguez TE, Pollock AN, Niles D, Meyer A, Myklebust H, Nysaether J, Nadkarni V. Estimation of optimal CPR chest compression depth in children by using computer tomography. Pediatrics. 2009 Jul;124(1):e69-74. doi: 10.1542/peds.2009-0153. |
| 25749553 | Derived | Tsui BC, Horne S, Tsui J, Corry GN. Generation of tidal volume via gentle chest pressure in children over one year old. Resuscitation. 2015 Jul;92:148-53. doi: 10.1016/j.resuscitation.2015.02.021. Epub 2015 Mar 4. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |