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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and cause of anovulatory infertility among reproductive aged women. According to the revised criteria of 2003, four distinct phenotypes of PCOS can be diagnosed. However, there are emerging evidence supporting the existence of different levels of cardiometabolic risk between the four phenotypic groups of the syndrome. The purpose of this study is to determine the cardiovascular risk of i) normoweight and ii)overweight plus obese women of every one of the four phenotypes of the syndrome as well as the levels of low inflammation serum markers and the possible correlations of the between the outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normoweight PCOS patients | |||
| normoweight controls | |||
| overweight plus obese PCOS patients | |||
| overwqeight plus obese controls |
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| Measure | Description | Time Frame |
|---|---|---|
| high sensitivity C-Reactive Protein (hsC-RP) levels and differences between the phenotypes | 1 hour | |
| Lipoprotein-associated phospholipase2 (Lp-PLA2) levels and differences between the phenotypes | 1 hour | |
| Cardiovascular Risk Assessment and differences between the phenotypes | 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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Outpatient women with PCOS (normalweight, overweight plus obese) Healthy volunteers controls (normalweight, overweight plus obese)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Georgios Daskalopoulos, M.D. | Contact | daskalog@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Second Department of Obstetrics and Gynecology, Third Department of Cardiology, Second Propedeutic Department of Internal Medicine, Aristotle University | Recruiting | Thessaloniki | Greece |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25600030 | Derived | Daskalopoulos G, Karkanaki A, Piouka A, Prapas N, Panidis D, Gkeleris P, Athyros VG. Excess Metabolic and Cardiovascular Risk is not Manifested in all Phenotypes of Polycystic Ovary Syndrome: Implications for Diagnosis and Treatment. Curr Vasc Pharmacol. 2015;13(6):788-800. doi: 10.2174/1567201812666150120163025. |
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| ID | Term |
|---|---|
| D011085 | Polycystic Ovary Syndrome |
| ID | Term |
|---|---|
| D010048 | Ovarian Cysts |
| D003560 | Cysts |
| D009369 | Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 |
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blood serum
|
| Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |