Low recruitment

This is a pilot study designed to investigate new techniques to guide the appropriate diagnosis and treatment of Ductal Carcinoma In-situ (DCIS). The microvascularity and stiffness of the lesion may be prognostic factors that can guide the need for more or less extensive therapy or perhaps only imaging follow-up may be needed.

Women who have imaging findings suggestive of DCIS, who are having breast ultrasound and who are candidates for surgery will be eligible. They will receive a contrast-enhanced breast ultrasound after the intravenous injection of a microbubble contrast agent which will show the microvascularity. A subset of women will also have ultrasound elastography performed of the abnormality to evaluate its stiffness.

Inclusion Criteria:

• A woman with imaging signs suggesting a diagnosis of DCIS who is scheduled for ultrasound and a biopsy is eligible for the study.
• At least 18 years of age

Exclusion Criteria:

• Pregnant or possibly pregnant or breast feeding
• Unable to provide informed consent
• Drug or multiple allergies
• Known cardiac shunts
• Known cardiac or chronic pulmonary disease
• Hypersensitivity to perflutren