Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Obesity is closely related to metabolic diseases and its prevalence is sharply increasing. However, there is no safe and effective treatment for obesity so far, the investigators need a breakthrough idea to curtail the constant threat of obesity. It has been recently demonstrated that emotional tears of women can modify sexual responses, one of basic instincts, in men. As appetite and food intake is another basic instinct, chemosignals from tears and plasma may modify appetite and eating behavior in humans.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tears | Experimental | Emotional tears of female volunteers while watching sad video clips |
|
| Saline | Placebo Comparator | Saline collected after being trickled down women's skin below eyes like tears |
|
| Fasting | Placebo Comparator | Their own overnight fasting plasma of male volunteers |
|
| Prandial | Experimental | Their own postprandial plasma of male volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sniffing emotional tears | Biological | A band-aid soaked 100μl of emotional tears will be applied just below nostrils. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The degree of appetite by visual analogue scale (VAS) and the amount of food intake by standard test meals in male volunteers while sniffing tears, trickled saline (control), and postprandial and fasting plasma in random order. | Visual analogue scale (VAS) will be rated 10 minutes after initial sniffing of tears/plasma just before eating standard test meals. The amount of food intake will be measured by weighing the meals before and after eating. |
| Measure | Description | Time Frame |
|---|---|---|
| Appetite regulating hormones(ghrelin, GLP-1, PYY), glucose, testosterone. Determination of tears, tickled saline, and plasma. | Blood samples for measuring appetite regulating hormones, glucose, testosterone will be collected at -10, 0, and 60 min. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Young Min Cho, MD, PHD | Seoul National University College of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Sniffing trickled saline | Biological | A band-aid soaked 100μl of trickled saline will be applied just below nostrils. |
|
|
| Sniffing fasting plasma | Biological | A band-aid soaked 100μl of own fasting plasma will be applied just below nostrils. |
|
|
| Sniffing postprandial plasma | Biological | A band-aid soaked 100μl of own postprandial plasma will be applied just below nostrils. |
|
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |