There is limited information on the long-term effects of treating patients with MPS VI with Naglazyme® and limited data on the natural history of treated and untreated MPS VI patients. The Re-survey Study ASB-00-03 will assist in understanding the effects of long-term Naglazyme treatment and the natural history of the MPS VI patient population.

Inclusion Criteria:

• Willing and able to provide written, signed informed consent, or in the case of patients under the age of 16 years, provide written assent (if required) and written informed consent by a legally authorized representative after the nature of the study has been explained, and prior to any research-related procedures.
• Previously participated in Survey Study ASB-00-02, and met the criteria of a MPS VI diagnosis.
• Willing to perform all study assessments and procedures as physically possible.

Exclusion Criteria:

• Concurrent disease or condition that would interfere with study participation or safety.
• Any condition that, in the view of the Investigator would place the patient at high risk of not completing the study.
• Concurrent enrollment and randomization into a clinical study of MPS VI treatment. Patients enrolled in the BioMarin MPS VI Clinical Surveillance Program may be enrolled in the Re-survey Study ASB-00-03.

Patients with MPS VI who previously participated in ASB-00-02