Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome

Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome

Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.

Inclusion Criteria:

• Patients undergoing isolated OPCAB.
• Age: 20~75.

Exclusion Criteria:

• Emergency operation.
• Patients with MR ≥ 2.
• Patients with IDDM.
• Patients with random sugar ≥ 250 mg/dL.
• Patients with serum creatinine ≥ 2.0 mg/dL.
• Patients with acute myocardial infarction within 1 week of surgery