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Inconsistent training status of sniffer dogs
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| Name | Class |
|---|---|
| Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) | OTHER |
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Previous studies have shown that specially trained sniffer dogs are capable to discriminate breath samples of patients with lung cancer and healthy individuals. So far it is not known whether this differentiation is specific for lung cancer or just identifies any form of (solid) tumor. Therefore, the dog's ability to differentiate between lung cancer, breast cancer and ovarian cancer is tested.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy individual | Sham Comparator | healthy individual with no lung disease and no history of cancer including lung cancer |
|
| lung cancer | Experimental | patients with histologically confirmed lung cancer, but no history of other cancer |
|
| breast cancer | Experimental | patients with histologically confirmed breast cancer, but no history of other cancer |
|
| ovarian cancer | Experimental | patients with histologically confirmed ovarian cancer, but no history of other cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exhalation analysis of breath sample | Other | study participants exhale 5 times into a test tube; test tube is presented to sniffer dogs for analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Specificity for Lung Cancer | exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with lung cancer from those of patients with other (tested) cancers | breath samples will be tested within 40 days after gathering |
| Measure | Description | Time Frame |
|---|---|---|
| Discriminability of breast and ovarian cancer | exhalation analysis by sniffer dogs is able to differentiate breath samples of patients with breast cancer from those of patients with other ovarian cancer | breath samples will be tested within 40 days after gathering |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thorsten Walles, MD | Schillerhoehe Hospital | Principal Investigator |
| Godehard Friedel, MD | Schillerhoehe Hospital | Study Chair |
| Wolfgang Simon, MD | Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Schillerhoehe Hospital | Gerlingen | Baden-Wurttemberg | 70839 | Germany | ||
| Robert Bosch Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22345057 | Background | Boedeker E, Friedel G, Walles T. Sniffer dogs as part of a bimodal bionic research approach to develop a lung cancer screening. Interact Cardiovasc Thorac Surg. 2012 May;14(5):511-5. doi: 10.1093/icvts/ivr070. Epub 2012 Feb 17. | |
| 21852337 | Background | Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur Respir J. 2012 Mar;39(3):669-76. doi: 10.1183/09031936.00051711. Epub 2011 Aug 18. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D001943 | Breast Neoplasms |
| D010051 | Ovarian Neoplasms |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Stuttgart |
| Baden-Wurttemberg |
| 70376 |
| Germany |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D004701 | Endocrine Gland Neoplasms |
| D010049 | Ovarian Diseases |
| D000291 | Adnexal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D000091662 | Genital Diseases |
| D004700 | Endocrine System Diseases |
| D006058 | Gonadal Disorders |