Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Kompetenznetz Leukämien | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Evaluation weather early chemotherapy attempts for remission induction can improve the results of patients with Acute Myeloid Leukemia (AML), as compared to the standard group.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| S-HAM | Experimental | S-HAM (S-HAMescalated for younger patients and S-HAMbasis for elderly patients) |
|
| TAD-HAM (younger) or HAM-HAM (elderly) | Active Comparator | is TAD-9 - HAM for younger patients (with 2 mandatory induction cycles) and HAM (- HAM) for the elderly patients with the second HAM cycle only applied in the case of inadequate blast clearance (> 5%) in the day 16 bone marrow aspirate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ara-C, Mitoxantrone, Daunorubicin, Thioguanin | Drug | Chemotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall response rate, aiming at a 15% increase in the CR/PR rate by S-HAM induction versus conventional double induction [TAD - HAM for younger patients, HAM (- HAM) for elderly patients]. | 8 years |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Wolfgang Hiddemann, Prof. Dr. | Hospital of the University of Munich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vinzenz-Pallotti-Hospital, Innere Abteilung | Bergisch Gladbach | 51429 | Germany | |||
| St. Hedwig Krankenhaus, Abteilung Innere Medizin |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40973764 | Derived | Cusan M, Larkin K, Nicolet D, Jurinovic V, Mrozek K, Batcha AMN, Rothenberg-Thurley M, Schneider S, Sauerland C, Gorlich D, Krug U, Berdel WE, Woermann BJ, Hiddemann W, Braess J, Spiekermann K, Greif PA, Blachly JS, Mims AS, Walker CJ, Walker MC, Oakes CC, Orwick S, Carroll AJ, Blum WG, Powell BL, Kolitz JE, Moore JO, Mayer RJ, Larson RA, Stone RM, Byrd JC, Metzeler KH, Herold T, Eisfeld AK. Multi-dimensional analysis of adult acute myeloid leukemia cross-continents reveals age-associated trends in mutational landscape and treatment outcomes (Acute Myeloid Leukemia Cooperative Group & Alliance for Clinical Trials in Oncology). Leukemia. 2025 Dec;39(12):2926-2934. doi: 10.1038/s41375-025-02644-0. Epub 2025 Sep 19. | |
| 38702786 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Berlin |
| 10115 |
| Germany |
| Vivantes Klinikum Neukoelln, Innere Medizin - Haematologie und Onkologie | Berlin | 12351 | Germany |
| HELIOS Klinikum Berlin-Buch, Klinik für Haematologie, Onkologie und Tumorimmunologie | Berlin | 13125 | Germany |
| Vivantes Klinikum Spandau, Klinik fuer Innere Medizin, Haematologie, Onkologie, Gastroenterologie und Palliativmedizin | Berlin | 13585 | Germany |
| Evangelisches Waldkrankenhaus Spandau | Berlin | 13589 | Germany |
| Evangelisches Krankenhaus Bielefeld gGmbH, Klinik fuer Innere Medizin, Haematologie, Onkologie und Palliativmedizin | Bielefeld | 44791 | Germany |
| Augusta-Krankenanstalt, Klinik fuer Haematologie, Onkologie und Palliativmedizin | Bochum | 44791 | Germany |
| Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Innere Medizin I | Bonn | 53113 | Germany |
| Knappschaftskrankenhaus Bottrop, Klinik fuer Innere Medizin | Bottrop | 46242 | Germany |
| Universitaetsklinikum Köln, Klinik I fuer Innere Medizin | Cologne | 50924 | Germany |
| St.-Johannes Hospital Dortmund, Klinik fuer Innere Medizin II | Dortmund | 44137 | Germany |
| St.-Antonius-Hospital Eschweiler, Klinik fuer Haematologie und internistische Onkologie | Eschweiler | 52249 | Germany |
| Klinikum Frankfurt / Oder GmbH, Medizinische Klinik I | Frankfurt (Oder) | 15236 | Germany |
| St.-Josef-Hospital Gelsenkirchen-Horst, Klinik für Medizinische und Radiologische Onkologie, Hämatologie und Palliativmedizin | Gelsenkirchen | 45899 | Germany |
| Städtisches Klinikum Gütersloh, Medizinische Klinik II | Gütersloh | 33332 | Germany |
| Kath. Krankenhaus Hagen GmbH, Klinik fuer Haematologie und Onkologie | Hagen | 58095 | Germany |
| Klinikum Herford, Medizinische Klinik II | Herford | 32049 | Germany |
| Klinikum Idar-Oberstein GmbH, Innere Medizin I, Abteilung Haematologie / Onkologie | Îdar-Oberstein | 55743 | Germany |
| Klinikum Leverkusen gGmbH, Medizinische Klinik III | Leverkusen | 51375 | Germany |
| Klinikum der Stadt Ludwigshafen am Rhein gGmbH, Medizinische Klinik A | Ludwigshafen | 67063 | Germany |
| Universitätsklinikum Schleswig-Holstein, Medizinische Klinik I, Haematologie / Onkologie | Luebbeck | 23538 | Germany |
| Medizinische Fakultaet Mannheim der Universitaet Heidelberg, III. Medizinische Klinik Haematologie und Internistische Onkologie | Mannheim | 68167 | Germany |
| Carl-von-Basedow-Klinikum Saalekreis GmbH, Medizinische Klinik II | Merseburg | 06217 | Germany |
| Krankenhaus Maria Hilf GmbH, Krankenhaus St. Franziskus, Medizinische Klinik I | Mönchengladbach | 41063 | Germany |
| Klinikum der Universitaet Muenchen Medizinische Klinik und Polikklinik III | München | 81377 | Germany |
| Staedtisches Klinikum Harlaching, Klinik für Onkologie und Haematologie | München | 81545 | Germany |
| Klinikum Osnabrück, Klinik fuer Haematologie / Onkologie | Osnabrück | 49076 | Germany |
| Brüderkrankenhaus St. Josef Paderborn, Klinik fuer Haematologie / Onkologie | Paderborn | 33098 | Germany |
| Krankenhaus Barmherzige Brüder , Klinik fuer internistische Onkologie und Haematologie | Regensburg | 93049 | Germany |
| St.-Marien-Krankenhaus Siegen gem. GmbH, Medizinische Klinik III | Siegen | 57072 | Germany |
| Stiftung Deutsche Klinik für Diagnostik GmbH, Zentrum fuer Knochenmark- und Stammzelltransplantation | Wiesbaden | 65191 | Germany |
| Derived |
| Archer KJ, Fu H, Mrozek K, Nicolet D, Mims AS, Uy GL, Stock W, Byrd JC, Hiddemann W, Braess J, Spiekermann K, Metzeler KH, Herold T, Eisfeld AK. Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model. J Hematol Oncol. 2024 May 3;17(1):28. doi: 10.1186/s13045-024-01553-6. |
| 37455345 | Derived | Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Gorlich D, Berdel WE, Wormann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K. Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome. Br J Haematol. 2023 Sep;202(6):1165-1177. doi: 10.1111/bjh.18982. Epub 2023 Jul 16. |
| 36064577 | Derived | Kunadt D, Stasik S, Metzeler KH, Rollig C, Schliemann C, Greif PA, Spiekermann K, Rothenberg-Thurley M, Krug U, Braess J, Kramer A, Hochhaus A, Scholl S, Hilgendorf I, Brummendorf TH, Jost E, Steffen B, Bug G, Einsele H, Gorlich D, Sauerland C, Schafer-Eckart K, Krause SW, Hanel M, Hanoun M, Kaufmann M, Wormann B, Kramer M, Sockel K, Egger-Heidrich K, Herold T, Ehninger G, Burchert A, Platzbecker U, Berdel WE, Muller-Tidow C, Hiddemann W, Serve H, Stelljes M, Baldus CD, Neubauer A, Schetelig J, Thiede C, Bornhauser M, Middeke JM, Stolzel F; A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL). Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation. J Hematol Oncol. 2022 Sep 5;15(1):126. doi: 10.1186/s13045-022-01339-8. |
| 30337300 | Derived | Konstandin NP, Pastore F, Herold T, Dufour A, Rothenberg-Thurley M, Hinrichsen T, Ksienzyk B, Tschuri S, Schneider S, Hoster E, Berdel WE, Woermann BJ, Sauerland MC, Braess J, Bohlander SK, Klein HG, Hiddemann W, Metzeler KH, Spiekermann K. Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA. Blood Adv. 2018 Oct 23;2(20):2724-2731. doi: 10.1182/bloodadvances.2018016840. |
| 24816240 | Derived | Hubmann M, Kohnke T, Hoster E, Schneider S, Dufour A, Zellmeier E, Fiegl M, Braess J, Bohlander SK, Subklewe M, Sauerland MC, Berdel WE, Buchner T, Wormann B, Hiddemann W, Spiekermann K. Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse. Haematologica. 2014 Aug;99(8):1317-25. doi: 10.3324/haematol.2014.104133. Epub 2014 May 9. |
| 22649106 | Derived | Greif PA, Dufour A, Konstandin NP, Ksienzyk B, Zellmeier E, Tizazu B, Sturm J, Benthaus T, Herold T, Yaghmaie M, Dorge P, Hopfner KP, Hauser A, Graf A, Krebs S, Blum H, Kakadia PM, Schneider S, Hoster E, Schneider F, Stanulla M, Braess J, Sauerland MC, Berdel WE, Buchner T, Woermann BJ, Hiddemann W, Spiekermann K, Bohlander SK. GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood. 2012 Jul 12;120(2):395-403. doi: 10.1182/blood-2012-01-403220. Epub 2012 May 30. |
| ID | Term |
|---|---|
| D015470 | Leukemia, Myeloid, Acute |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D003561 | Cytarabine |
| D008942 | Mitoxantrone |
| D003630 | Daunorubicin |
| ID | Term |
|---|---|
| D003562 | Cytidine |
| D011741 | Pyrimidine Nucleosides |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001087 | Arabinonucleosides |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D000880 | Anthraquinones |
| D000095322 | Anthrones |
| D000873 | Anthracenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011809 | Quinones |
| D011083 | Polycyclic Compounds |
| D018943 | Anthracyclines |
| D009279 | Naphthacenes |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
Not provided
Not provided