DNA Methylation and Urothelial Carcinoma

Level of DNA Methylation in People With Urothelial Carcinoma

Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.

Inclusion Criteria:

• Clinical diagnosis of urothelial carcinoma
• The voluntary of participating the study

Exclusion Criteria:

• Age smaller than 20 years
• Pregnant women
• Not willing to participate the study because of their personal reasons