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The aim of the study is to evaluate if the Step up protocol is equal or superior regarding efficacy and security than the step down protocol. In couple submitted two intrauterine insemination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Step Down | Experimental | Step Down: We begin the COS (controlled ovarian stimulation) with 150 IU of FSH-r until 7th day of stimulation. This day we make an adjustment reducing the dose if necessary. |
|
| Step Up | Active Comparator | Step up: We begin the COS (controlled ovarian stimulation) with 75 IU of FSH-r until 7th day of stimulation.This day we make an adjustment increasing the dose if necessary. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FSH-r (Follicule stimulate hormone) | Drug | Step-Up: 75 IU FSH-r Step-Down: 150 FSH-r |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ovulation rate | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital del Mar | Barcelona | 08003 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35243855 | Derived | Robles A, Gayete-Lafuente S, Prat M, Gonzalez-Comadran M, Checa MA. The step-up protocol increases clinical pregnancy rates compared with the step-down in patients with unexplained infertility. A randomized controlled trial. JBRA Assist Reprod. 2022 Nov 9;26(4):599-605. doi: 10.5935/1518-0557.20210112. |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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