Effects of Cariprazine on Cardiac Repolarization in Patients With Schizophrenia

Evaluation of the Effects of Sequential Multiple-Dose Regimens of Cariprazine on Cardiac Repolarization in Patients With Schizophrenia

This study will evaluate the effects of sequential multiple dose regimens of cariprazine on cardiac repolarization in patients with schizophrenia.

Inclusion Criteria:

• Men or women, age 18 to 50, inclusive
• Symptoms of schizophrenia or schizoaffective disorder first appearing a minimum of 1 year before screening
• Negative pregnancy test
• Normal physical examination results, vital signs, and clinical lab test results

Exclusion Criteria:

• Axis II disorder severe enough to interfere with the study
• Smoking more than 20 cigarettes a day
• History or presence of cardiovascular disorder
• Pregnant/breast-feeding and/or planning to become pregnant/breast-feed
• Imminent risk of injuring self or others or causing significant property damage