Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement

Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging

The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.

Inclusion Criteria:

• healthy volunteers between the ages of 18-75 years old

Exclusion Criteria:

• subjects taking vasoactive medications
• hypertension or vascular disease
• asthma
• smokers
• pregnant women
• cancer
• diabetes mellitus
• history of seizures
• history of stroke or head trauma
• subjects taking digoxin, cyclosporine,felodipine, estradiol, or quinolone antibiotics
• poor transcranial Doppler insonation windows